PM295. Association between autism susceptibility candidate 2 haplotypes and alcohol dependence in a Japanese population

s | 5 Conclusions: Aripiprazole demonstrated its efficacy in maintaining abstinence from metamphetamine use in Thai patients with metamphetamine dependence following metamphetamine psychosis. It was found to be safe and well tolerated. Keyword: methamphetamine, aripiprazole, dependence, abstinence PM294 Association between polymorphism of COMT gene and domestic violence in Han and Uygur on alcoholics in Xinjiang ShaohongZou, MannaHu, HowardHuang, ZongfengZhao, XiangdongXu, HongbinDong Corresponding author: ShaohongZou Department of Clinical Psychology, People’s Hospital of XinJiang Uygur Autonomous Region, 91 Tianchi Road,Urumqi,Xinjiang, China. 830001, Tel:+8613699973051. E-mail:[email protected] Abstract Objective: The domestic violence may be related a number of neurotransmitters, and its associated gene, especially polymorphism of catecholamine-O-methyltransferase(COMT) gene, and gene expression. Herein, we sought to investigate the association between COMT gene rs4680、rs4818 polymorphism and domestic violence in Han and Uygur on alcoholics in Xinjiang. Methods: The methods of PCR and Direct PCR sequencing were conducted to detect rs4680 and rs4818 single nucleotide polymorphism loci of COMT gene in 208 domestic violence perpetrators and 180 normal controls. The association between the polymorphisms and violent behavior was analyzed with SPSSl7.0. The SHEsis program was applied to perform the combined effect analysis of the paired SNPs. Results: The frequency of the genotypes and alleles of rs4680 and rs4818 polymorphisms in the domestic violence group were not statistically different from those in the normal control group(P>0.05).The two groups were divided in Han and Uygur ethnic group. The frequency of the genotypes and alleles of rs4680 and rs4818 polymorphisms in the domestic violence Uygur and Han ethnic group were not statistically different from those in the normal control group(P>0.05). The results in Han and Uygur ethnic group of the combined effect analysis showed that rs4818-rs4680 in the domestic violence group were not statistically different from those in the normal control group(P>0.05). Conclusion: COMT gene rs4818、rs4680 polymorphism may be not associated with domestic violence on alcoholics in Xinjiang.